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doi: 10.3389/fmicb.2021.800442 [DOI] [PMC free article] [PubMed] [Google Scholar] [39].Vega-Chacn Y, de Albuquerque M, Pavarina A, et al
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In addition to the parasympathetic regulation, acetylcholine is currently suggested to be a paracrine signal of peripheral tissues, particularly in pancreas and epithelial cells (168, 169)
Such interactions create crosstalk between epigenetic layers: MeCP2, a methyl-DNA binding protein, can recruit histone modifiers, while histone acetylation status influences DNA methyltransferase access to chromatin 181,182